New International Research Project Improves Lives For Alzheimer’s Sufferers
Article by RealWire
DECIDE infrastructure combines high speed GÉANT and national research networks with powerful computers to enable earlier diagnosis and treatment
Cambridge, UK, 10 October 2011 – A ground breaking international research project that aims to help sufferers from Alzheimer’s Disease and other dementia conditions has been showcased at the Alzheimer Europe conference, which ended yesterday.
DECIDE (Diagnostic Enhancement of Confidence by an International Distributed Environment) uses high speed research links such as the pan-European GÉANT network to help doctors make earlier, more informed diagnoses, improving the quality of life for Alzheimer’s sufferers and their carers. Begun in November 2010, the first version of the service, based on Statistical Parametric Modelling (SPM) techniques, has been validated and tested in the first half of 2011 prior to wider release. At the Alzheimer Europe event, the project is demonstrating the potential of the GriSPM algorithm, which evaluates brain metabolism and perfusion, comparing these markers with existing data to aid both diagnosis and research.
With no cure for dementia conditions such as Alzheimer’s and an estimated 750,000 sufferers in the UK alone (and 7.3 million in Europe), the medical focus is on earlier diagnosis to help ensure patients receive the best care possible. DECIDE works by allowing doctors to access its secure portal through their web browser and upload patient medical scans. It then uses grid computing and high speed networks to handle the intensive processing needed to analyse the data, extracting any markers that demonstrate the onset of Alzheimer’s and providing the results back to the doctor.
Through the use of advanced medical imaging technology, the neurological data that researchers and clinicians collect is increasing dramatically. However as data has grown, so has the computing power needed to manage and analyse it, making it too difficult and expensive for individual hospitals.
DECIDE solves this issue by bringing together high speed research networks, distributed databases, powerful diagnostic algorithms and grid computing to provide a secure, user-friendly service to clinicians across Europe. Currently DECIDE has over 1,000 CPU computing processors, with 70 terabytes of storage and is working in partnership with the pan-European GÉANT network, as well as Italian national network GARR, to design a network that matches its needs. GÉANT works with types of medical networks and to make it seamless and transparent to the end user, GÉANT’s perfSONAR monitoring tool is being used to monitor service across the multiple network domains that make up the DECIDE infrastructure.
“Enabling earlier diagnosis of conditions such as Alzheimer’s is critical to improved patient care,” said Fulvio Galeazzi, DECIDE Project Coordinator. “DECIDE will ensure that the diagnostic process is much more straightforward and simple, using distributed computing resources and the power of the GÉANT network to create an advanced e-infrastructure that spans the entire European medical community and enable clinicians to make better informed decisions, at the click of a mouse. Our demonstration at the Alzheimer Europe event showed the potential of the service both in research and underpinning earlier diagnoses.”
DECIDE, which is funded by the European Union, is an international project that brings together 13 research teams and organisations from across Europe. These include the Imperial College of Science, Technology and Medicine in London, GARR, the Italian research and education network, Alzheimer Europe and the Centre Hospitalier Universitaire de Toulouse (France), acting on behalf of the European Alzheimer Disease Consortium.
“To analyse the growing mountain of medical data now available to doctors requires a powerful computing infrastructure that needs to operate internationally to facilitate the close collaboration between clinicians and researchers,” said Niels Hersoug, Joint General Manager of DANTE, the organisation which on behalf of Europe’s NRENs has built and operates the GÉANT network. “What is vital about the DECIDE project is that while it uses complex technology, it is simple, secure and easy to use for doctors, and delivers major benefits to patients and their families, dramatically improving their quality of life. Together with the NRENs, the GEANT network provides the networking capability necessary for this important application.”
Looking forward, the researchers will also develop other diagnostic algorithms to search for new markers within the DECIDE infrastructure. In the longer term the infrastructure could also be extended to cover algorithms relating to other diseases of the brain and other organs, involving the whole life science research community.
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The aim of DECIDE (Diagnostic Enhancement of Confidence by an International Distributed Environment) is to design, implement, and validate a GRID-based e-Infrastructure building upon neuGRID and relying on the Pan-European backbone GEANT and the National Research Networks (NRENs).
Over this e-Infrastructure, a service will be provided for the computer-aided extraction of diagnostic markers for Alzheimer’s disease and schizophrenia from medical images. DECIDE will offer access to large distributed reference databases (850 and 2200 datasets from normal subjects and from neurological subjects, respectively), high computation and storage resources (more than 1000 CPU core processors and 70 Tbyte of storage) and intensive image processing tools.
DECIDE will be open to the implementation of future algorithms based on other neuroimaging methods; in a longer-term perspective, the infrastructure could be extended to other research and diagnostic algorithms relating other diseases of the brain and other organ systems.
For more information: http://www.eu-decide.eu, info@eu-decide.eu.
