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Peripheral Artery Disease

October 12, 2011 By Leave a Comment

Peripheral Artery Disease

Article by Rockwell Fitness









PERIPHERAL ARTERY DISEASE SYMPTOMS

Many cases of peripheral artery disease manifest no visible symptoms, because symptoms include intermittent claudication symptoms. Sometimes the symptoms are just mild and not noticeable. Intermittent claudication symptoms include muscle pain or cramping in your legs or arms that’s triggered by activity, such as walking, but disappears after a few minutes of rest. The location of the pain depends on the location of the clogged or narrowed artery. Calf pain is most common. This pain will vary from mild to severe pain that even will extend the pain to not be able to walk. The area affected will be cold to touch compared to the leg not affected. There will be sores on the leg of foot affected that this sores tend not heal. Slower growth of the toenails. And the area of the skin is shinny. These are just some of the symptoms. If experience let it be checked on a doctor right away.

PERIPHERAL ARTERY DISEASE TREATMENT

Treatment for peripheral artery disease has two major goals. The first is to manage symptoms, such as leg pain, so that you can resume physical activities. The second is to stop the progression of atherosclerosis throughout your body to reduce your risk of heart attack and stroke. Symptom-relief medications. The drug cilostazol (Pletal) increases blood flow to the limbs both by preventing blood clots and by widening the blood vessels. It specifically helps the symptom of claudication, leg pain, for people who have peripheral artery disease. Common side effects of this medication include headache and diarrhea. An alternative to cilostazol is pentoxifylline (Trental); however, it’s generally less effective. But, side effects are rare with this medication. Angioplasty and surgery in some cases, angioplasty or surgery may be necessary to treat peripheral artery disease that’s causing intermittent claudication. There are several synthetic treatments of PAD and be sure to be diagnose with proper procedure for right treatment.

PAD PERIPHERAL ARTERY DISEASE

Peripheral artery disease is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs. Person with PAD?s especially the extremities will not received enough blood supply to the legs. And will have extreme pain when the leg affected will be use, like walking, running, and swimming. There will be accumulation of fatty acids in the arteries that often times reduced blood flow to the heart and brain and mostly to the affected area.



About the Author

What is Peripheral Artery Disease and how does it affect us. To know more about Peripheral Artery Disease.Visit us.










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Innovative Vascular Therapies for Patients with End-stage Renal Disease and Peripheral Arterial Disease

September 30, 2011 By Leave a Comment

Innovative Vascular Therapies for Patients with End-stage Renal Disease and Peripheral Arterial Disease

Article by Suzanne Benz









Michael Belkin, MD, Chief of the Division of Vascular and Endovascular Surgery, and Michael S. Conte, MD, Director of Vascular Surgery Research in the Cardiovascular Center at Brigham and Women?s Hospital, are pioneering techniques and leading clinical trials to improve patency of vein grafts and hemodialysis access procedures, as well as salvage limbs and prevent the progression of peripheral arterial disease.

Advances in Cell Therapy to Improve Dialysis Access OutcomesGrafts and fistulas placed in hemodialysis patients frequently fail, requiring numerous procedures and adversely affecting quality-of-life for these patients. New cell therapies are being developed to reduce the narrowing of vessels caused by scarring and abnormal tissue growth. Dr. Conte is the Co-lead Investigator of an FDA-approved, multicenter Phase I/II study assessing the efficacy and feasibility of Vascugel?, a new allogeneic cell therapy that strives to restore natural repair and regeneration pathways in the vasculature.

Sponsored by Pervasis Therapeutics, the V-HEALTH trial (Vascular Intimal Hyperplasia: Extending Arterial and Venous Patency, Limiting Vascular Trauma, and Inhibiting Hyperplasia While Re-establishing Vascular Health) is suitable for patients with end-stage renal disease (ESRD) who require permanent arteriovenous (AV) access ? including AV grafts and AV fistulas ? for hemodialysis. The study may also have broader implications for patients with peripheral arterial disease.

Biologic Therapies to Improve Clinical Outcomes of Vascular InterventionsResults of past studies of biologic interventions employing cells, genes, or other biological products in cardiovascular disease have been mixed but provide valuable insight for researchers and physicians. Vascular surgeons at Brigham and Women?s Hospital have pioneered efforts to improve the results of bypass surgery for patients with severe vascular disease. Dr. Conte served as lead investigator of a large, multicenter, randomized Phase III trial, The Project or Ex-Vivo vein graft Engineering via Transfection III (PREVENT III), assessing the effectiveness of the molecular therapy edifoligide in preventing vein graft failure in patients with critical limb ischemia (CLI).

While the recently published study concluded that this treatment did not reduce the incidence of vein graft stenosis in a large cohort of patients, the study demonstrated the safety and feasibility of delivering genetic material to vein grafts in the operating room setting, with the goal of re-engineering bypasses that are resistant to failure. Further investigations of this approach are warranted. In addition, the large clinical database resulting from PREVENT III has also allowed the investigators to make important new discoveries regarding risk factors for adverse outcomes following leg bypass surgery.

Other AdvancesExperts in cardiovascular medicine and vascular surgery at Brigham and Women?s Hospital are collaborating in key research studies of factors contributing to peripheral arterial disease and vein graft disease. Mark A. Creager, MD, Director of the Vascular Center, Paul M. Ridker, MD, Director of the Center for Cardiovascular Disease Prevention, and Dr. Conte are leading a team of researchers in NIH-sponsored studies of:

The role of inflammation and insulin resistance in the development and progression of peripheral arterial disease;The relationship of inflammation and insulin resistance to vein graft disease.

Multidisciplinary Approach to CareThe Cardiovascular Center offers a multidisciplinary approach to vascular care and full range of treatment options for patients with carotid artery disease, aortic aneurysms, peripheral arterial disease, and hemodialysis access needs. Vascular surgeons offer a full range of procedures, including minimally invasive endovascular repair, angioplasty/stenting, carotid endarterectomy, and surgical bypass procedures to restore circulation and prevent limb loss.

These specialists are working to develop improved approaches to identify and treat patients at risk, improve their walking function, and prevent the progression of disease in the native arteries or bypass grafts by targeting inflammatory processes. Patients are currently being recruited for several different arms of this prospective study.

Other actively enrolling clinical trials within the Division of Vascular and Endovascular Surgery include trials of carotid artery stenting, endovascular aneurysm repair, and angioplasty/ stenting of lower extremity vessels.

Indications for ReferralPatients with the following conditions may be referred for evaluation and treatment:

Patients with ESRD requiring vein fistulas or grafts for hemodialysis access;Patients with lower extremity pain due to peripheral arterial disease;Patients with diabetic foot conditions and impaired circulation;Patients with aneursymal disease of the thoracic or abdominal aorta;Patients with carotid artery occlusive disease.

Information and ReferralsFor more information regarding vascular surgery techniques at Brigham and Women?s Hospital, or to refer a patient, please contact a Referral Coordinator at (617) 732-9894.



About the Author

Brigham and Women’s Hospital?s neuroscience center offers neurology services with the care & compassion you would expect from an organization that has been consistently ranked as one of America?s best hospitals on the U.S. News & World Report® Honor Roll, and one of the top neurology & neurosurgery providers in the country.










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“peripheral Arterial Disease (Pad) – Drug Pipeline Analysis And Market Forecasts To 2016″ Added On Visionshopsters

September 23, 2011 By Leave a Comment

“peripheral Arterial Disease (Pad) – Drug Pipeline Analysis And Market Forecasts To 2016″ Added On Visionshopsters

The industry analysis specialist’s new report, “Peripheral Arterial Disease – Drug Pipeline Analysis and Market Forecasts to 2016″” is an essential source of information and analysis on the global peripheral arterial disease market. The report identifies the key trends shaping and driving the global peripheral arterial disease market. The report also provides insight on the prevalent competitive landscape and the emerging players expected to bring significant shift in the market positioning of the existing market leaders. Most importantly, the report provides valuable insight on the pipeline products within the global peripheral arterial disease sector.

This report is built using data and information sourced from proprietary databases, primary and secondary research and in house analysis by GlobalData’s team of industry experts.

Scope

The scope of the report includes:
– Annualized global peripheral arterial disease market revenues data from 2001 to 2009, forecast forward for 7 years to 2016.
– Geographic markets covered in this report include the US (United States), the UK (United Kingdom), Italy, Spain, Germany, France, and Japan.
– Pipeline analysis data providing a split across different phases, mechanism of action being developed and emerging trends.
– Analysis of the current and future market competition in the global peripheral arterial disease market. Key players covered include Sanofi-Aventis, Indigo Pharmaceuticals, Sigma-tau Pharmaceuticals Inc, and BioMarin Pharmaceuticals.

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– Insightful review of the key industry drivers, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications.
– Key topics covered include strategic competitor assessment, market characterization, unmet needs and implications for the future market associated with peripheral arterial disease.

Reasons to buy

The report will enhance your decision making capability in a more rapid and time sensitive manner. It will allow you to:
– Develop and design your in-licensing and out-licensing strategies through review of pipeline products and technologies and by identifying companies with the most robust pipeline.
– Develop business strategies by understanding the trends shaping and driving the global peripheral arterial disease market.
– Drive revenues by understanding key trends, innovative products and technologies, market segments and companies likely to impact the global peripheral arterial disease market in future.
– Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors.
– Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
– Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.
– What’s the next big thing in the global peripheral arterial disease market landscape? – Identify, understand and capitalize.

Companies Mentioned

Sanofi-Aventis
Indigo Pharmaceuticals
Sigma-tau Pharmaceuticals Inc.
BioMarin Pharmaceuticals

To know more about this report & to buy a copy please visit :
http://www.visionshopsters.com/product/1240/Peripheral-Arterial-Disease-PAD-Drug-Pipeline-Analysis-and-Market-Forecasts-to-2016.html

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Visionshopsters
Ph : 91-22-40583000
Emailid: marketing@visionshopsters.com
Website : www.visionshopsters.com

VisionShopsters.com specializes in providing comprehensive collection of online market research reports, conference/events/seminars bookings, country reports, company profiles, latest books and magazines, customized research services offering informative solutions worldwide. We constantly believe in providing inventive solutions to clients all across the globe.

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Peripheral Artery Disease Facts

September 23, 2011 By Leave a Comment

Peripheral Artery Disease Facts

PAD is a really serious illness, since it can cause amputation of the extremities, rupture of an aortic aneurysm, severe hypertension, kidney failure, but also heart attack, stroke, and cardiovascular death.Peripheral arterial disease has, as its primary lesion, the same initial plaque which is responsible for other conditions associated with atherosclerosis, e.g., coronary artery disease and cerebral vascular insufficiency. In the lower limbs, the posterior tibial artery at the ankle and the anterior tibial artery at its origin are the most commonly affected arteries with atherosclerosis.

The blockage in the arteries means that the blood flow is reduced. At rest there is enough oxygen in the blood reaching the muscles to prevent any symptoms. When walking the calf muscles need more oxygen, but because the blood flow is restricted the muscles cannot obtain enough oxygen from the blood and cramp occurs. This is made better by resting for a few minutes. If greater demands are made on the muscles, such as walking uphill, the pain comes on more quickly. Many patients also notice that if they are carrying heavy bags the pain comes on sooner because the leg muscles are having to work harder.

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The most common cause of peripheral arterial disease (PAD) is atherosclerosis. In atherosclerosis, fatty deposits (plaques) build up in your artery walls and reduce blood flow. PAD mimics a condition similar to coronary artery disease and carotid artery disease where fatty deposits build up in the inner linings of the artery walls. These blockages restrict blood circulation, mainly in arteries leading to the kidneys, stomach, arms, legs, and feet.

There are two main causes for Peripheral Artery Disease: One is a lack of the (right kind of exercise).

As we age, we increasingly take the path of least resistance when performing tasks in order to avoid pain or discomfort. The veins and arteries in the areas of our body where restrictions and blockages normally occur that cause PAD, no longer receive the stimulation and stretching necessary to maintain sufficient flexibility to allow blood to flow freely.

Another cause of Peripheral Artery Disease is out of balance Cholesterol levels. When veins and arteries lose their elasticity, it provides the opportunity for deposits to build up in areas where the veins and arteries haven’t been exercised and dormant for an extended period of time. This is where the restrictions and blockages occur causing less blood supply to the lower extremities.

Conventional medical treatments cannot cure Peripheral Artery Disease. If you have PAD you already know that the best you can hope for when using conventional medical treatments is to slow the progression of the disease (not cure it).

Stents, Bypass Surgery, Balloon Angioplasty, Arterial Reaming, and Prescription Drugs do not address the underlying cause of the disease. At best they can only provide temporary relief. By not taking the initiative to seek out proven alternative solutions that work, and allowing the progression of Peripheral Artery Disease to continue or remain static, can lead to serious problems such as: Heart Disease, Stroke, Blood Clots, Gangrene, Amputation, and decreased blood flow to the brain.

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